Metabolic Disease

CIR Biopharma's in vivo pharmacodynamics team has rich experience in constructing animal models of metabolic diseases and in vivo pharmacology research, and has constructed a variety of metabolic disease models. To meet the differentiated needs of customers, the team can provide customized services to develop suitable animal models and appropriate in vivo pharmacodynamic study for our customers.


Osteoporosis model
  • Osteoporosis model of castrated female rat

  • Glucocorticoid-induced osteoporosis model in rats

  • Retinoic acid A induced osteoporosis model in rats


Cholestasis model
  • Bile duct ligation cholestasis model in rats

  • DDC-induced cholestasis model in mice


Diabetes model
  • ZDF rat diabetes model

  • db/db mouse diabetes model

  • ob/ob mouse diabetes model


Liver disease model
  • Non-alcoholic steatohepatitis(NASH)mouse model

  • TAA-induced mouse liver fibrosis model


HFD-induced rat/mouse obesity model

High fat/fructose diet induced hyperlipidemia model