Systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is an autoimmune-mediated, diffuse connective tissue disease characterized by immune inflammation. The exact cause of the disease is unknown, but may be related to genetics, environmental factors and estrogen. Symptoms are varied and often include fever, photosensitivity, rash, enlarged lymph nodes, muscle and joint pain, headaches, and fatigue et al.
Clinical features
The patient's body produces large amounts of autoantibodies, causing the immune system to attack its own tissues;
Multiple organ and tissue involvement throughout the body.
Test index
Skin injury
dsDNA content within plasma
Urine protein
Lymphadenectasis
Kidney histopathological examination, etc
Tsokos GC. N Engl J Med. 2011; 365(22): 2110-21.
Animal SLE models
