Experimental autoimmune encephalomyelitis

Experimental autoimmune encephalomyelitis (EAE) is an autoimmune disease mediated by specifically sensitized CD4+ T cells and characterized by the presence of MC infiltration around small blood vessels and myelin sheath loss within the CNS, and its pathological changes are similar to those of MS.

  • Commonly used sensitizing antigens:Myeloid oligodendrocyte glycoprotein (MOG),Myelin basic protein (MBP);Protein lipid (PLP), etc.

  • A clinical classification of 5 levels of neurological function based on behavioral manifestations is usually used to judge the degree of morbidity.

实验性自身免疫性脑脊髓炎.jpg

Paul S, et al., J Leukoc Biol. 2015; 97(2):259-71.


Animal EAE models

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