Delayed type hypersensitivity

Delayed type hypersensitivity (DTH) is an inflammatory response caused by Macrophages, in which T cells are sensitized after exposure to the corresponding antigen and are activated when continuously exposed or re-exposed to the same antigen.

  • T cells activate macrophages through cytotoxic action or release cytokines, and infiltrate tissues, resulting in tissue damage, erythema, swelling and inflammation.

  • Short-term stimulation with hapten (DNFB) induced contact allergic dermatitis in mice with predominantly Th1-type cellular immunity, and sustained and repeated exposure to hapten induced Th2-type cutaneous inflammation similar to that seen in human atopic dermatitis.

  • These heapten-induced animal models are simple and can be established repeatedly in large quantities, and they are one of the most commonly used models for studying the pathological mechanisms of related diseases and screening therapeutic drugs.


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https://blog.sciencenet.cn/blog-279293-1406897.html


Delayed hypersensitivity reaction（DTH）animal model

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