Tumor model in immunodeficient rat

Tumor model in immunodeficient rat

SRG rats of severe immunodeficiency

  • Sprague Dawley-Rag2em2hera112rgem1hera/HblCrl；

  • The part fragments of Rag2 and Il2ry genes were knocked out in SD rats, resulting in the absence of T, B and NK cells, and showing severe immune deficiency；

  • 2016, Hera Biolabs introduction from Transposagen；

  • 2021, Charles River Laboratories introduction from Hera Biolabs;

  • 2022, Vital River introduced the strain core group from Charles River.


SRG rats of severe immunodeficiency

Application

The SRG rats have multiple immune deficiencies and physiological characteristics of rats, which can provide unique advantages in applications such as oncology, immunology, xenotransplantation and humanized immune system reconstitution.

  • Large body weight, high tumor loading capacity, and large sample size acquisition;

  • Long lifespan, supporting long-term multiple experiments;

  • Easy operation: orthotopic operation, intubation, blood collection;

  • High quality receptors for extended passage of tumor samples.


Humanization of the SRG™ rat immune system with PBMCs

重度免疫缺陷SRG大鼠.jpg