In Vitro ADME

In the early stage of drug development, it is very important to examine the absorption, distribution, metabolism, excretion and other characteristics of drug candidates. Pharmacokinetic studies can evaluate the drugability of compounds, which is valuable for improving the efficiency of new drug development and reducing the risk of failure at the late stage of development. With rich experience in in vitro ADME and sound platform, we can provide services for our clients' drug research and development.


Permeability

  • Type: Caco-2, MDCK, MDR1-MDCK.


Plasma protein binding

  • Methods: equilibrium dialysis, ultrafiltration, etc.; Species: mouse, rat, dog, monkey, human, etc..


Metabolic stability

  • Study system: whole blood, plasma, liver microsome, liver cells, etc.; Species: mouse, rat, dog, monkey, human, etc..


Identification of metabolites

  • Study system: liver microsomes, liver cells, plasma, urine, feces, bile, etc.;  Species: mouse, rat, dog, monkey, human, etc..


Drug-drug interaction

  • CYP450 enzyme phenotype, induction and inhibition tests.